Biochem/physiol Actions
Reversible: yes
Product competes with ATP.
Primary TargetMyosin light chain kinase (Mlck)
Target Ki: 300 nM against myosin light chain kinase
Cell permeable: yes
General description
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM)and protein kinase C (Ki = 42 µM) at much higher concentrations.
A cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.Saitoh, M., et al. 1987. J. Biol. Chem.262, 7796.
Packaging
1 mg in Plastic ampoule
Preparation Note
Further dilute with aqueous buffer just prior to use.
Reconstitution
Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
Warning
Toxicity: Standard Handling (A)
This product has met the following criteria to qualify for the following awards: